Background: DNMT3B polymorphisms are associated with the susceptibility of lung cancer. DNMT3B âË?â??2437T>A is a\nnovel polymorphism, and its influence on the risk of lung cancer in Chinese was investigated in this study. In addition,\neffect of DNMT3B âË?â??149C>T polymorphism on lung cancer was also explored.\nMethods: Genotyping in subjects were performed by PCR-RFLP. Haplotype frequencies were estimated by estimating\nhaplotype software. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by unconditional\nlogistic regression analysis.\nResults: Neither of the two polymorphisms was correlated with lung cancer (âË?â??149C>T: CT+TT vs CC: OR = 0.78, 95%CI,\n0.57 to 1.05, P = 0.361; âË?â??2437T>A: AT+AA vs TT: OR = 0.99, 95%CI, 0.74 to 1.33, P = 0.168). In stratification\nanalysis, T-allele carrier genotype of âË?â??149C>T polymorphism resulted in a reduced lung cancer risk at stage II,\ncompared with CC (OR = 0.46, 95%CI, 0.28 to 0.77, P = 0.023). In haplotype analysis, when âË?â??149C/âË?â??2437T was\nused as reference, the other combined genotypes of the two polymorphisms had no significant effect on\nlung cancer risk (P > 0.05).\nConclusions: The two DNMT3B polymorphisms are not correlated with lung cancer risk among Chinese\npopulation nor the haplotype of them.
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